Nanzhong 南中 was a region in the southwest of China during Later Han and the Three Kingdoms period. The region lay in the south of Yi Province and consisted of four commanderies (jùn 郡), which were Yizhou 益州, Yuexi 越巂, Zangke 牂柯 and Yongchang 永昌.

During Shu-Han's reign of Yi Province the Nanzhong natives rebelled twice because they did not acknowledge the reign of Shu-Han.

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